Synonyms
Neurogenin1 [Neurog1; Ngn1; Math4C; bHLHa6; Neurod3]; Neurogenin2 [Neurog2; Ngn2; Math4A; bHLHa8; Atoh4]; Neurogenin3 [Neurog3; Ngn3; Math4B; bHLHa7; Atoh5]
Historical Background
Neurogenins (Neurog or Ngn) belong to a family of proneural proteins that play essential roles in cell fate determination during neurogenesis (Fig. 1a). They belong to a large class of basic helix-loop-helix (bHLH) transcription factors, which contains a conserved helix-loop-helix dimerization domain and a basic region providing DNA-binding activity (Fig. 1b) (Guillemot 1999). Proneural bHLH genes are both necessary and sufficient to initiate neuronal differentiation in a cell-autonomous manner and they are expressed at the correct time and place to select neural precursors for neuronal commitment.
Structure, function, and conservation. (a) Phylogenetic tree of proneural basic helix-loop-helix (bHLH) transcription factors, based on protein sequence similarities in the bHLH domain....
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Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development. 2011;138:4267–77.
Anthwal N, Pelling M, Claxton S, Mellitzer G, Collin C, Kessaris N, Richardson WD, Gradwohl G, Ang SL. Conditional deletion of neurogenin-3 using Nkx2.1iCre results in a mouse model for the central control of feeding, activity and obesity. Dis Model Mech. 2013;6:1133–45.
Azzarelli R, Hardwick LJ, Philpott A. Emergence of neuronal diversity from patterning of telencephalic progenitors. Wiley Interdiscip Rev Dev Biol. 2015;4:197–214.
Bertrand N, Castro DS, Guillemot F. Proneural genes and the specification of neural cell types. Nat Rev Neurosci. 2002;3:517–30.
Fode C, Ma Q, Casarosa S, Ang SL, Anderson DJ, Guillemot F. A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev. 2000;14:67–80.
Gohlke JM, Armant O, Parham FM, Smith MV, Zimmer C, Castro DS, Nguyen L, Parker JS, Gradwohl G, Portier CJ, et al. Characterization of the proneural gene regulatory network during mouse telencephalon development. BMC Biol. 2008;6:15.
Gradwohl G, Dierich A, LeMeur M, Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA. 2000;97:1607–11.
Guillemot F. Vertebrate bHLH genes and the determination of neuronal fates. Exp Cell Res. 1999;253:357–64.
Heinrich C, Blum R, Gascon S, Masserdotti G, Tripathi P, Sanchez R, Tiedt S, Schroeder T, Gotz M, Berninger B. Directing astroglia from the cerebral cortex into subtype specific functional neurons. PLoS Biol. 2010;8:e1000373.
Heng J, Guillemot F. Proneural proteins and the development of the cerebral cortex. In: Cortical development: neural diversity and neocortical organization. 2013; Tokyo: Springer. p 54419–41. https://doi.org/10.1007/978-4-431-54496-8.
Heng JI, Nguyen L, Castro DS, Zimmer C, Wildner H, Armant O, Skowronska-Krawczyk D, Bedogni F, Matter JM, Hevner R, et al. Neurogenin 2 controls cortical neuron migration through regulation of Rnd2. Nature. 2008;455:114–8.
Li S, Mattar P, Zinyk D, Singh K, Chaturvedi CP, Kovach C, Dixit R, Kurrasch DM, Ma YC, Chan JA, et al. GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex. J Neurosci. 2012;32:7791–805.
Ma Q, Kintner C, Anderson DJ. Identification of neurogenin, a vertebrate neuronal determination gene. Cell. 1996;87:43–52.
Masserdotti G, Gillotin S, Sutor B, Drechsel D, Irmler M, Jorgensen HF, Sass S, Theis FJ, Beckers J, Berninger B, et al. Transcriptional mechanisms of proneural factors and REST in regulating neuronal reprogramming of astrocytes. Cell Stem Cell. 2015;17:74–88.
Mellitzer G, Bonne S, Luco RF, Van De Casteele M, Lenne-Samuel N, Collombat P, Mansouri A, Lee J, Lan M, Pipeleers D, et al. IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. EMBO J. 2006;25:1344–52.
Sancho R, Gruber R, Gu G, Behrens A. Loss of Fbw7 reprograms adult pancreatic ductal cells into alpha, delta, and beta cells. Cell Stem Cell. 2014;15:139–53.
Serafimidis I, Rakatzi I, Episkopou V, Gouti M, Gavalas A. Novel effectors of directed and Ngn3-mediated differentiation of mouse embryonic stem cells into endocrine pancreas progenitors. Stem Cells. 2008;26:3–16.
Shimojo H, Ohtsuka T, Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron. 2008;58:52–64.
Sommer L, Ma Q, Anderson DJ. neurogenins, a novel family of atonal-related bHLH transcription factors, are putative mammalian neuronal determination genes that reveal progenitor cell heterogeneity in the developing CNS and PNS. Mol Cell Neurosci. 1996;8:221–41.
Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008;455:627–32.
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Azzarelli, R. (2018). Neurogenins. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101798
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101798
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