Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Roberta AzzarelliEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101798


 Neurogenin1 [Neurog1; Ngn1; Math4C; bHLHa6; Neurod3];  Neurogenin2 [Neurog2; Ngn2; Math4A; bHLHa8; Atoh4];  Neurogenin3 [Neurog3; Ngn3; Math4B; bHLHa7; Atoh5]

Historical Background

Neurogenins (Neurog or Ngn) belong to a family of proneural proteins that play essential roles in cell fate determination during neurogenesis (Fig. 1a). They belong to a large class of basic helix-loop-helix (bHLH) transcription factors, which contains a conserved helix-loop-helix dimerization domain and a basic region providing DNA-binding activity (Fig. 1b) (Guillemot 1999). Proneural bHLH genes are both necessary and sufficient to initiate neuronal differentiation in a cell-autonomous manner and they are expressed at the correct time and place to select neural precursors for neuronal commitment.
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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Wellcome Trust Centre for Stem Cell Research and Department of OncologyUniversity of CambridgeCambridgeUK