Secretin and the secretin receptor hold special places in history, with the discovery of the biological activity of this peptide hormone by Bayliss and Starling in 1902 representing the first humoral mediator identified and launching the field of endocrinology and with the description of this receptor by Ishihara et al. in 1991 representing the first class B G protein-coupled receptor (GPCR) identified. Both of these events marked the beginning of exciting and important chapters in biomedical history. The class B GPCRs comprise a small family within this superfamily, including receptors for only a small number of moderate length peptides (also including receptors for vasoactive intestinal polypeptide, pituitary adenylate cyclase-activating peptide, glucagon, glucagon-like peptides 1 and 2, glucose-dependent insulinotropic polypeptide, calcitonin, calcitonin gene-related peptide, amylin, adrenomedullin, parathyroid hormone, parathyroid...
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