Phosphatidylinositol 4-Kinase Type II Alpha
Phosphatidylinositol 4-kinase type II α, also commonly referred to as PI4K2A or PI4KIIα, is a 54 kDa lipid kinase that catalyzes the phosphorylation of the membrane lipid phosphatidylinositol on the D4 position of its inositol headgroup to produce phosphatidylinositol 4-phosphate (PI4P). There are three other phosphatidylinositol 4-kinases expressed in most mammalian cells, PI4KB, PI4KA, and PI4KB. PI4K2A is highly homologous to the PI4KB isozyme, and together they are classified as the type II phosphatidylinositol 4-kinases (reviewed in Boura and Nencka 2015; Clayton et al. 2013). The type II phosphatidylinositol kinases differ from the type III PI4KA and PI4KB isozymes in that they are insensitive to the phosphoinositide 3-kinase inhibitors wortmannin and LY-294002, but are inhibited by low micromolar concentrations of adenosine....
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