The undecapeptide substance P (SP) belongs to the tachykinin peptide family (hemokinin 1 (HK-1), neurokinin A (NKA), and B (NKB) are also included in this family). This family of peptides exerts many biological actions through three receptors named neurokinin-1, neurokinin-2, and neurokinin-3. The neurokinin-1 receptor (NK-1R) shows a preferential affinity for SP/HK-1, NK-2R for NKA, and NK-3R for NKB (Pennefather et al. 2004). The affinity of the NK-1R for NKA and NKB is, respectively, 100- and 500-fold lower than for SP (Gerard et al. 1991). SP, after binding to the NK-1R, exerts many biological actions (Muñoz and Coveñas 2014). The NK-1R protein is encoded by the TACR1 gene (Takeda et al. 1991). In humans, this gene is located on chromosome 2 and spans 45–60 kb, and it is contained in five exons (Gerard et al. 1991). The NK-1R belongs to the 1 (rhodopsin-like) G...
The authors wish to thank Mr. Javier Muñoz (University of Seville, Spain) for technical assistance.
- Gillespie E, Leeman SE, Watts LA, Coukos JA, O’Brien MJ, Cerda SR, Farraye FA, Stucchi AF, Becker JM. Truncated neurokinin-1 receptor is increased in colonic epithelial cells from patients with colitis-associated cancer. Proc Natl Acad Sci U S A. 2011;108:17420–5.PubMedPubMedCentralCrossRefGoogle Scholar
- Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Carlson EJ, Hargreaves RJ, Rupniak NM. Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science. 1998;281:1640–5.CrossRefPubMedGoogle Scholar
- Theoharides TC, Zhang B, Kempuraj D, Tagen M, Vasiadi M, Angelidou A, Alysandratos KD, Kalogeromitros D, Asadi S, Stavrianeas N, Peterson E, Leeman S, Conti P. IL-33 augments substance P-induced VEGF secretion from human mast cells and is increased in psoriatic skin. Proc Natl Acad Sci U S A. 2010;107:4448–53.PubMedPubMedCentralCrossRefGoogle Scholar