Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Shannon E. Weeks
  • Swapnil Bawage
  • Lalita A. Shevde
  • Rajeev S. SamantEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101779


 DJ4;  DnaJ;  HHDJ1;  HSJ-2;  HSJ2;  LGMD1D;  LGMD1E;  MRJ;  MSJ-1

Historical Background

Heat shock proteins were first identified in the late 1970s by Dr. Alfred Tissieres laboratory who noticed that when Drosophila cells in culture were exposed to 37 °C a new set of proteins were synthesized (Arrigo et al. 1980). These proteins have been identified as heat shock proteins (HSP) and play a role in a wide variety of biological processes. Heat shock proteins act as chaperones helping move various client proteins to different cellular compartments. They also ensure the client proteins are folded correctly, as well as aid in degradation of misfolded or damaged proteins (Mitra et al. 2009). Since then, many heat shock proteins have been identified, including DNAJB6. It was initially identified for its role in the development of the embryo and placenta (Hunter et al. 1999). Recently, however, its role in cancer and many other diseases has been investigated.

Structure and Isoforms of...

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NIH R01CA194048 grant to R.S.S.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Shannon E. Weeks
    • 1
  • Swapnil Bawage
    • 1
  • Lalita A. Shevde
    • 1
  • Rajeev S. Samant
    • 1
    Email author
  1. 1.Division of Molecular and Cellular Pathology, Department of PathologyUniversity of Alabama at BirminghamBirminghamUSA