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Encyclopedia of Signaling Molecules pp 3534–3541Cite as

N-Myc and STAT Interactor (NMI)

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Synonyms

N-myc and STAT interactor; N-myc interactor; NMI

Historical Background

N-myc interactor, NMI, was first characterized as an interactor of c-Myc and n-Myc using a yeast two-hybrid screen. Since its initial discovery, NMI has been studied for its roles in viral pathologies and more extensively for its role in cancer progression. However, literature describing the role of NMI function in normal physiology is relatively unknown aside from inferences from its roles in various pathologies. NMI is a protein mostly studied for its associations with known transcription factors. In humans, expression profiling has determined that NMI is expressed in all fetal tissues except in the brain and primarily in the adult spleen, liver, and kidneys. The human NMI gene is located on chromosome 2q23 and contains three exons that can form four alternatively spliced mRNA transcripts; two with no retained introns code for protein products (Bao and Zervos 1996). NMI’s expression is largely...

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References

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Acknowledgments

NIH R01CA194048 grant to R.S.S.

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Authors and Affiliations

  1. Division of Molecular and Cellular Pathology, Department of Pathology, University of Alabama at Birmingham, Wallace Tumor Institute, 1824 6th Ave. S., Birmingham, AL, USA

    Brandon J. Metge, Hawley C. Pruitt & Rajeev S. Samant

  2. Division of Molecular and Cellular Pathology, Department of Pathology and Comprehensive Cancer Center, University of Alabama at Birmingham, Wallace Tumor Institute, Birmingham, AL, USA

    Lalita A. Shevde

  3. Department of Pathology and Comprehensive Cancer Center, The University of Alabama, Birmingham, AL, USA

    Rajeev S. Samant

Authors
  1. Brandon J. Metge
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  2. Hawley C. Pruitt
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  3. Lalita A. Shevde
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  4. Rajeev S. Samant
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Corresponding author

Correspondence to Rajeev S. Samant .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Metge, B.J., Pruitt, H.C., Shevde, L.A., Samant, R.S. (2018). N-Myc and STAT Interactor (NMI). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101778

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