Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101773


Historical Background

Human RASSF6 gene is registered as one of the Ras-association domain family in the databank. RASSF6 was first referred in the paper reporting the association of SNPs in RASSF6 with susceptibility to respiratory syncytial virus bronchiolitis (Hull et al. 2004). The researchers discussed based on the structural feature and the potential function of RASSF6 in the regulation of cytoskeletal structure, gene expression, and cell-cell interactions. Thereafter, RASSF6 was identified as an interactor with a junctional protein named membrane-associated guanylate kinase with an inverted arrangement of protein-protein interaction domains (MAGI1) (Ikeda et al. 2007). RASSF6 was also identified from the EST database by tblastn using the Ras-association (RA) domain of RASSF1 (Allen et al. 2007).

Structure of RASSF6

In the GenBank database, four human RASSF6...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Medical Biochemistry, Graduate School of Medical and Dental SciencesTokyo Medical and Dental UniversityTokyoJapan
  2. 2.Center for Brain Integration ResearchTokyo Medical and Dental UniversityTokyoJapan