Human RASSF6 gene is registered as one of the Ras-association domain family in the databank. RASSF6 was first referred in the paper reporting the association of SNPs in RASSF6 with susceptibility to respiratory syncytial virus bronchiolitis (Hull et al. 2004). The researchers discussed based on the structural feature and the potential function of RASSF6 in the regulation of cytoskeletal structure, gene expression, and cell-cell interactions. Thereafter, RASSF6 was identified as an interactor with a junctional protein named membrane-associated guanylate kinase with an inverted arrangement of protein-protein interaction domains (MAGI1) (Ikeda et al. 2007). RASSF6 was also identified from the EST database by tblastn using the Ras-association (RA) domain of RASSF1 (Allen et al. 2007).
Structure of RASSF6
- Guo W, Dong Z, Guo Y, Shen S, Guo X, Kuang G, et al. Decreased expression and frequent promoter hypermethylation of RASSF2 and RASSF6 correlate with malignant progression and poor prognosis of gastric cardia adenocarcinoma. Mol Carcinog. 2015; https://doi.org/10.1002/mc.22416.CrossRefPubMedPubMedCentralGoogle Scholar
- Richter AM, Zimmermann T, Haag T, Walesch SK, Dammann RH. Promoter methylation status of Ras-association domain family members in pheochromocytoma. Front Endocrinol (Lausanne). 2015;6:21.Google Scholar