Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Shinobu KitazumeEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101772


Historical Background

Platelet endothelial cell adhesion molecule (PECAM) is a 130-kDa membrane glycoprotein and a member of the immunoglobulin (Ig) gene superfamily. PECAM was initially found in platelets (Newman et al. 1982); subsequently, it was also identified in endothelial cells (Newman et al. 1990) and leukocyte subtypes (Dangerfield et al. 2002). Because of its abundant expression in endothelial cells, PECAM is also recognized as an endothelial cell marker for immunohistochemical analyses. PECAM is a multifunctional signaling molecule regulating platelet function, thrombosis, vascular integrity, leukocyte transmigration, and leukocyte immune response (Newman and Newman 2003; Woodfin et al. 2007). In addition, as a critical mechanosensor protein, endothelial PECAM senses...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.RIKEN-Max Planck Joint Research Centre for Systems Chemical Biology, Global Research ClusterRIKENSaitamaJapan