Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Osteopontin (Spp1)

  • Swapnil Bawage
  • Shannon E. Weeks
  • Lalita A. Shevde
  • Rajeev S. SamantEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101771


Historical Background

The protein product of gene Spp1 is known by many names; however, osteopontin (OPN) is the most widely used and preferred. Osteopontin was first identified in osteoblasts and is primarily known for its role in bone mineralization, hence derives the name “osteo” for bone and pontin from “pons”- bridge in Latin. Orthologous gene analysis of Spp1 gene indicates that it is found in 39 eukaryotic genera. In humans, OPN is expressed in many organs and plays an important role in many cellular, physiological, immunological, and...

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NIH R01CA194048 grant to R.S.S.


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Swapnil Bawage
    • 1
  • Shannon E. Weeks
    • 1
  • Lalita A. Shevde
    • 3
  • Rajeev S. Samant
    • 1
    • 2
    Email author
  1. 1.Division of Molecular and Cellular Pathology, Department of PathologyUniversity of Alabama at Birmingham, Wallace Tumor InstituteBirminghamUSA
  2. 2.Department of Pathology and Comprehensive Cancer CenterThe University of AlabamaBirminghamUSA
  3. 3.Division of Molecular and Cellular Pathology, Department of Pathology and Comprehensive Cancer CenterUniversity of Alabama at Birmingham, Wallace Tumor InstituteBirminghamUSA