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RASD1

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

AGS1, Activator of G-protein Signaling 1; DEXRAS1, Dexamethasone-inducible RAS protein 1; RASD1, Ras dexamethasone-induced 1

Historical Background

DEXRAS1/RASD1/AGS1 was identified in three independent studies from 1998 to 2000. In 1998, Kemppainen and Behrend isolated a novel gene that was rapidly induced by the synthetic glucocorticoid, dexamethasone, in AtT-20 mouse pituitary tumor cells. They coined this new gene dexamethasone-inducible Ras protein 1 based on its homology to other members of the Ras superfamily of small GTPases (Kemppainen and Behrend 1998). A year later, Dexras1/Rasd1 was discovered in a yeast functional screen designed to identify mammalian genes that activate the pheromone response pathway in the absence of the pheromone receptor (Cismowski et al. 1999). It was given the name activator of G-protein signaling 1 (AGS1) based on its ability to activate G proteins in a G protein-coupled receptor (GPCR)-independent manner (Cismowski et al. 1999; Cismowski...

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References

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Authors and Affiliations

  1. Department of Biology, University of Toronto Mississauga, 3359 Mississauga Road, Mississauga, ON, Canada

    Pascale Bouchard-Cannon & Hai-Ying Mary Cheng

  2. Department of Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, ON, Canada

    Pascale Bouchard-Cannon & Hai-Ying Mary Cheng

Authors
  1. Pascale Bouchard-Cannon
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  2. Hai-Ying Mary Cheng
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Correspondence to Hai-Ying Mary Cheng .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Bouchard-Cannon, P., Cheng, HY.M. (2018). RASD1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101764

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