Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

DREAM (Downstream Regulatory Element Antagonist Modulator)

  • Stephen Pastore
  • Hai-Ying Mary Cheng
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101763

Synonyms

Historical Background

In 1998, Carrión et al. discovered a 110 kDa protein complex present in nuclear extracts of human neuroblastoma cells that could bind to a small region of DNA (+36 to +44 relative to the transcription start site) within the 5′ untranslated region (5′-UTR) of the human prodynorphin gene. Occupancy of this DNA element, termed the downstream regulatory element (DRE), by the protein complex caused a significant attenuation in prodynorphin gene transcription (Carrión et al. 1998). Utilizing a double-stranded DRE oligonucleotide probe to screen a human caudate expression library, Carrión et al. (1999) subsequently cloned the gene encoding for the DRE-binding protein, which they named downstream regulatory element antagonist modulator (DREAM). Electrophoretic mobility shift assays (EMSAs) confirmed that DREAM can bind to DRE and that the...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of BiologyUniversity of Toronto MississaugaMississaugaCanada
  2. 2.Department of Cell and Systems BiologyUniversity of TorontoTorontoCanada