Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Xiaogang Chu
  • Ryan George
  • Raghavan RajuEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101761



The Sir2 family of proteins were first discovered in Saccharomyces cerevisiae. The sirtuins, class III histone deacetylases (HDAC), are NAD+-dependent protein deacetylases and regulate posttranslational acyl modifications in organisms ranging from bacteria to humans (Haigis and Guarente 2006; Nakagawa and Guarente 2011). The seven sirtuin proteins (SIRT1–SIRT7) in mammals have a conserved core NAD+-binding domain and have diverse substrate proteins, intracellular localizations, and cellular functions (Anderson et al. 2014; Nakagawa and Guarente 2011).


The sirtuin family of proteins shares a conserved catalytic core of approximately 275 amino acids among most organisms. The acetylated peptide and the NAD+ are bound within a cleft that separates a small zinc-binding domain and a large Rossmann-fold domain. Several invariant amino acids are...

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The work was supported (RR) by a grant (R01GM101927) from the National Institutes of Health, Bethesda, MD, USA.


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Augusta UniversityAugustaUSA