Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Polo-Like Kinase (PLK)

  • Nitin Sharma
  • Rajni Vaid
  • Kamal Dev
  • Anuradha SourirajanEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101760


 CaCdc5 (PLK in Candida albicans);  Cdc5 (PLK in Saccharomyces cerevisiae);  Plk1/SmPlk1;  Plk4/SmSak (PLKs in Schistosoma mansoni);  PLK1;  PLK2/hSNK;  PLK3/PRK;  PLK4/SAK;  PLK5 (PLKs in Homo sapiens);  Plk1;  Plk2/SNK;  PLK3/FNK;  Plk4 and Plk5 (PLKs in Mus musculus);  plk1;  plk2;  plk3;  ZYG-1 (PLKs in Caenorhabditis elegans);  PLK1;  PLK2;  PLK4/SAK (PLKs in Strongylocentrotus purpuratus);  plk1;  plk2b;  plk3;  plk4 (PLKs in Danio rerio);  PLKA (PLK in Aspergillus nidulans);  plo1 (PLK in Schizosaccharomyces pombe);  Plx1;  Plx2;  Plx3 (PLK in Xenopus laevis);  TbPLK (PLK in Trypanosoma brucei).

Historical Background

Different protein kinases govern the progression of cell cycle by the phosphorylation of an array of their respective substrates. The key cell cycle kinases are polo-like kinase (PLK), cyclin-dependent kinase (CDK), and aurora kinases (AURK), which are evolutionarily conserved in eukaryotes from yeast to humans (Vaid et al. 2016). Polo-like kinases are...

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© Springer International Publishing AG 2018

Authors and Affiliations

  • Nitin Sharma
    • 1
  • Rajni Vaid
    • 1
  • Kamal Dev
    • 1
  • Anuradha Sourirajan
    • 1
    Email author
  1. 1.Faculty of Applied Sciences and BiotechnologyShoolini UniversitySolanIndia