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Encyclopedia of Signaling Molecules pp 4253–4257Cite as

Protein-Glutamine Gamma-Glutamyltransferase

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Synonyms

Fibrin stabilizing factor; Fibrinoligase; Glutaminylpeptide gamma-glutamyltransferase; Polyamine transglutaminase; R-glutaminyl-peptide:amine gamma-glutamyl transferase; TG; TGase; Transglutaminase

Historical Background

Transglutaminases (TGs) are a family of enzymes (EC 2.3.2.13) that catalyze the formation of amide bonds between proteins to form insoluble cross-linked protein aggregates that are resistant to chemicals, detergents, and proteases degradation (Griffin et al. 2002; Yokoyama et al. 2004).

TG activity was first observed in 1957 by Clarke et al. (1957), when they found an enzyme with transamidating properties extracted from guinea pig liver. Only in 1959 the name transglutaminase was assigned by Waelsch and collaborators (Mycek et al. 1959), in order to distinguish this enzymatic activity from that of other enzymes with similar activity.

TGs catalyzes posttranslational cross-link reactions between two substrates that can be two proteins or two residues of the same...

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References

  • Ando H, Adachi M, Umeda K, Matsuura A, Nonaka M, Uchio R, Tanaka H, Motoki M. Purification and characteristics of a novel transglutaminase derived from microorganisms. Agric Biol Chem. 1989;53:2613–7.

    CAS  Google Scholar 

  • Beninati S, Piacentini M. The transglutaminase family: an overview: minireview article. Amino Acids. 2004;26(4):367–72.

    PubMed  CAS  Google Scholar 

  • Clarke DD, Neidle A, Sarkar NK, Waelsch H. Metabolic activity of protein amide groups. Arch Biochem Biophys. 1957;71(1):277–9.

    Article  CAS  PubMed  Google Scholar 

  • Collighan RJ, Griffin M. Transglutaminase 2 cross-linking of matrix proteins: biological significance and medical applications. Amino Acids. 2009;36(4):659–70.

    Article  CAS  PubMed  Google Scholar 

  • Connellan JM, Chung SI, Whetzel NK, Bradley LM, Folk JE. Structural properties of guinea pig liver transglutaminase. J Biol Chem. 1971;246(4):1093–8.

    PubMed  CAS  Google Scholar 

  • Cortez J, Bonner PL, Griffin M. Transglutaminase treatment of wool fabrics leads to resistance to detergent damage. J Biotechnol. 2005;116(4):379–86.

    Article  CAS  PubMed  Google Scholar 

  • Del Duca S, Serafini-Fracassini D. Transglutaminases of higher, lower plants and fungi. Prog Exp Tumor Res. 2005;38:223–47.

    Article  CAS  PubMed  Google Scholar 

  • Della Mea M, Caparros-Ruiz D, Claparols I, Serafini-Fracassini D, Rigau J. AtPng1p: the first plant transglutaminase. Plant Physiol. 2004;135(4):2046–54.

    Article  CAS  PubMed  Google Scholar 

  • Facchiano F, Facchiano A, Facchiano AM. The role of transglutaminase-2 and its substrates in human diseases. Front Biosci. 2006;11:1758–73.

    Article  CAS  PubMed  Google Scholar 

  • Folk JE, Chung SI. Molecular and catalytic properties of transglutaminases. Adv Enzymol Relat Areas Mol Biol. 1973;38:109–91.

    PubMed  CAS  Google Scholar 

  • Folk JE, Cole PW. Mechanism of action of guinea pig liver transglutaminase. I. Purification and properties of the enzyme: identification of a functional cysteine essential for activity. J Biol Chem. 1966;241(23):5518–25.

    PubMed  CAS  Google Scholar 

  • Griffin M, Casadio R, Bergamini CM. Transglutaminases: nature’s biological glues. Biochem J. 2002;368(Pt 2):377–96.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gundemir S, Colak G, Tucholski J, Johnson GV. Transglutaminase 2: a molecular Swiss army knife. Biochim Biophys Acta. 2012;1823(2):406–19.

    Article  CAS  PubMed  Google Scholar 

  • Kanaji T, Ozaki H, Takao T, Kawajiri H, Ide H, Motoki M, Shimonishi Y. Primary structure of microbial transglutaminase from Streptoverticillium sp. strain s-8112. J Biol Chem. 1993;268(16):11565–72.

    PubMed  CAS  Google Scholar 

  • Kuraishi C, Yamazaki K, Susa Y. Transglutaminase: its utilization in the food industry. Food Rev Intl. 2001;17(2):221–46.

    Article  CAS  Google Scholar 

  • Lentini A, Abbruzzese A, Provenzano B, Tabolacci C, Beninati S. Transglutaminases: key regulators of cancer metastasis. Amino Acids. 2013;44(1):25–32.

    Article  CAS  PubMed  Google Scholar 

  • Lorand L, Graham RM. Transglutaminases: crosslinking enzymes with pleiotropic functions. Nat Rev Mol Cell Biol. 2003;4(2):140–56.

    Article  CAS  PubMed  Google Scholar 

  • Mehta K. Mammalian transglutaminases: a family portrait. Prog Exp Tumor Res. 2005;38:1–18.

    Article  CAS  PubMed  Google Scholar 

  • Mycek MJ, Clarke DD, Neidle A, Waelsch H. Amine incorporation into insulin as catalyzed by transglutaminase. Arch Biochem Biophys. 1959;84:528–40.

    Article  CAS  PubMed  Google Scholar 

  • Porta R, Giosafatto CV, di Pierro P, Sorrentino A, Mariniello L. Transglutaminase-mediated modification of ovomucoid: effects on its trypsin inhibitory activity and antigenic properties. Amino Acids. 2013;44(1):285–92.

    Article  CAS  PubMed  Google Scholar 

  • Serafini-Fracassini D, Del Duca S. Transglutaminases: widespread cross-linking enzymes in plants. Ann Bot. 2008;102(2):145–52.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Serafini-Fracassini D, Della Mea M, Tasco G, Casadio R, Del Duca S. Plant and animal transglutaminases: do similar functions imply similar structures? Amino Acids. 2009;36(4):643–57.

    Article  CAS  PubMed  Google Scholar 

  • Shi YG, Qian L, Zhang N, Han CR, Liu Y, Zhang YF, Ma YQ. Changes in morphology and activity of transglutaminase following cross-linking and immobilization on a polypropylene microporous membrane. Molecules. 2011;16(12):10046–58.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tabolacci C, Lentini A, Provenzano B, Beninati S. Evidences for a role of protein cross-links in transglutaminase-related disease. Amino Acids. 2012;42(2–3):975–86.

    Article  CAS  PubMed  Google Scholar 

  • Teixeira LS, Feijen J, van Blitterswijk CA, Dijkstra PJ, Karperien M. Enzyme-catalyzed crosslinkable hydrogels: emerging strategies for tissue engineering. Biomaterials. 2012;33(5):1281–90.

    Article  CAS  PubMed  Google Scholar 

  • Yokoyama K, Nio N, Kikuchi Y. Properties and applications of microbial transglutaminase. Appl Microbiol Biotechnol. 2004;64(4):447–54.

    Article  CAS  PubMed  Google Scholar 

  • Zeugolis DI, Panengad PP, Yew ES, Sheppard C, Phan TT, Raghunath M. An in situ and in vitro investigation for the transglutaminase potential in tissue engineering. J Biomed Mater Res A. 2010;92(4):1310–20.

    PubMed  CAS  Google Scholar 

  • Zhang J, Wang S, Huang W, Bennett DA, Dickson DW, Wang D, Wang R. Tissue transglutaminase and its product isopeptide are increased in alzheimer’s disease and APPswe/PS1dE9 double transgenic mice brains. Mol Neurobiol. 2016;53(8):5066–78.

    Article  CAS  PubMed  Google Scholar 

  • Zhu Y, Rinzema J, Tramper J, Bol J. Microbial transglutaminase: a review of its production and application in food processing. Appl Microbiol Biotechnol. 1995;44(3–4):277–82.

    Article  CAS  Google Scholar 

  • Zhu Y, Tramper J. Novel applications for microbial transglutaminase beyond food processing. Trends Biotechnol. 2008;26(10):559–65.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. CEB - Centre of Biological Engineering, University of Minho, 4710-057, Braga, Portugal

    Ivone M. Martins

  2. CIMO-Mountain Research Center, Agricultural College of Bragança, Polytechnic Institute of Bragança, 5301-855, Bragança, Portugal

    Altino Choupina

Authors
  1. Ivone M. Martins
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  2. Altino Choupina
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Corresponding author

Correspondence to Altino Choupina .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Martins, I.M., Choupina, A. (2018). Protein-Glutamine Gamma-Glutamyltransferase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101758

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