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Encyclopedia of Signaling Molecules pp 1283–1287Cite as

CYR61/CCN1

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Synonyms

CCN1 (CYR61 CTGF NOV 1); CYR61 (cysteine-rich protein 61)

Historical Background

CYR61/CCN1 belongs to the family of CCN matricellular proteins, first described 25 years ago. The other members consist of CTGF/CCN2 (connective tissue growth factor) and NOV/CCN3 (neuroblastoma overexpressed) and Wnt-induced signaling pathway proteins 1–3 (CCN4–CCN6). They constitute a family of proteins with conserved domain structures (Fig. 1). CCN1 was first described as an immediate early gene induced by mitogens in fibroblasts (O’Brien et al. 1990). It has now been implicated in numerous biological processes such as cell adhesion, migration, proliferation, and death with altered expression in cancer or vascular diseases (Emre and Imhof 2014).

CYR61/CCN1, Fig. 1
figure 4221 figure 4221

CCN protein family

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References

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Authors and Affiliations

  1. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland

    Yalin Emre

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  1. Yalin Emre
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Correspondence to Yalin Emre .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Emre, Y. (2018). CYR61/CCN1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101754

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