Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Josep A. VillenaEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101752


Historical Background

PGC-1α is the founding member of a small family of transcriptional coactivators that also includes PGC-1β and PRC (PGC-1-related coactivator). The three members of the family share structural features and exert their regulatory action on gene expression by binding and coactivating an overlapping wide range of transcription factors and nuclear receptors. Although each of the PGC-1 coactivators exhibits some specific functional peculiarities, particularly in the cellular context or physiological situation in which they exert their function, the three members of the family are nowadays considered key...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Laboratory of Metabolism and ObesityVall d’Hebron – Institut de Recerca, Universitat Autònoma de BarcelonaBarcelonaSpain
  2. 2.CIBER on Diabetes and Associated Metabolic Diseases (CIBERDEM)MadridSpain