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Encyclopedia of Signaling Molecules pp 3219–3224Cite as

Mrck

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Synonyms

CDC42 binding protein kinase (DMPK-like); Cdc42bp; Myotonic dystrophy kinase-related CDC-42 binding kinase; Myotonic dystrophy protein kinase-like; Ser-thr protein kinase PK428; Ser-thr protein kinase related to the myotonic dystrophy protein kinase; Serine/threonine-protein kinase MRCK

Historical Background

MRCK stands for Myotonic dystrophy-Related Cdc42-binding Kinase. The protein earned this name because it binds to Cdc42 with a significant homology to the DMPK (Dystrophia Myotonica Protein Kinase) kinase domain. Prior to the identification of MRCK, many of the RHO-family GTPase effectors homologous to MRCK were discovered. After the identification of the RHO-family GTPases, Rho, Rac1, and Cdc42 (Manser et al. 1994), each of which plays distinctive roles in cytoskeletal reorganization associated with growth and differentiation, the search began for the interacting proteins and potential targets of the p21 (Cdc42/Rac) Rho family that might convey signals downstream to...

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References

  • Bishop A, Hall A. Rho GTPases and their effector proteins. Biochem J. 2000;348:241–55.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Choi S, Czifra G, Kedei N, Lewin N, Lazar J, Pu Y, Marquez V, Blumberg P. Characterization of the interaction of phorbol esters with the C1 domain of MRCK alpha/beta. J Biol Chem. 2008;283:10543–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Heikkila T, Wheatley E, Crighton D, Schroder E, Boakes A, Kaye S, Mezna M, Pang L, Rushbrooke M, Turnbull A. Co-crystal structures of inhibitors with MRCKβeta, a key regulator of tumor cell invasion. PLoS One. 2011;6:e24825.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Huo L, Wen W, Wang R, Kam C, Xia J, Feng W, Zhang M. Cdc42-dependent formation of the ZO-1/MRCKβ complex at the leading edge controls cell migration. EMBO. 2011;30:665–78.

    Article  CAS  Google Scholar 

  • Kale V, Hengst J, Desai D, Dick T, Choe K, Colledge A, Takahashi Y, Sung S, Amin S, Yun J. A novel selective multikinase inhibitor of ROCK and MRCK effectively blocks cancer cell migration and invasion. Cancer Lett. 2014;354:299–310.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Leung T, Chen X-QQ, Manser E, Lim L. The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeleton. Mol Cell Biol. 1996;16(10):5313–27.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Leung T, Chen X-QQ, Tan I, Manser E, Lim L. Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. Mol Cell Biol. 1998;18:130–40.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lowe H, Watson C, Badal S, Toyang N, Bryant J. Cycloartane3,24,25-triol inhibits MRCKα kinase and demonstrates promising anti prostate cancer activity in vitro. Cancer Cell Int. 2012;12:46.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature. 1994;367(6458):40–6.

    Article  CAS  PubMed  Google Scholar 

  • Moncrieff C, Bailey M, Morrison N, Johnson K. Cloning and chromosomal localization of human Cdc42-binding protein kinase beta. Genomics. 1999;57:297–300.

    Article  CAS  PubMed  Google Scholar 

  • Ng Y, Tan I, Lim L, Leung T. Expression of the human myotonic dystrophy kinase-related Cdc42-binding kinase g is regulated by promoter DNA methylation and Sp1 binding. J Biol Chem. 2004;279(33):34156–66.

    Article  CAS  PubMed  Google Scholar 

  • Tan I, Seow K, Lim L, Leung T. Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. Mol Cell Biol. 2001;21(8):2767–78.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Tan I, Cheong A, Lim L, Leung T. Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase a reveals multiple alternative splicing and functional diversity. Gene. 2003;304:107–15.

    Article  CAS  PubMed  Google Scholar 

  • Unbekandt M, Croft D, Crighton D, Mezna M, McArthur D, McConnell P, Schuttelkopf A, Belshaw S, Pannifer A, Sime M, Bower J, Drysdale M, Olson M. A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Comm Signal. 2014;12:54.

    Article  CAS  Google Scholar 

  • Wilkinson S, Paterson H, Marshall C. Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. Nat Cell Biol. 2005;7(3):255–61.

    Article  CAS  PubMed  Google Scholar 

  • Zhao Y, Loyer P, Li H, Valentine V, Kidd V, Kraft A. Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. JBC. 1997;15(11):10013–20.

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Penn State University College of Medicine, Hershey, PA, 17033, USA

    Laura Geffert & Jong Yun

Authors
  1. Laura Geffert
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  2. Jong Yun
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Corresponding author

Correspondence to Jong Yun .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Geffert, L., Yun, J. (2018). Mrck. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101741

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