Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Mucins (MUCs)

  • Rahat Jahan
  • Sukhwinder Kaur
  • Muzafar A. Macha
  • Surinder K. BatraEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101739
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  1. Apostolopoulos V, Stojanovska L, Gargosky SE. MUC1 (CD227): a multi-tasked molecule. Cell Mol Life Sci. 2015;72:4475–500. doi:10.1007/s00018-015-2014-z.CrossRefPubMedGoogle Scholar
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  15. Kitamoto S, Yokoyama S, Higashi M, Yamada N, Matsubara S, Takao S, Batra SK, Yonezawa S. Expression of MUC17 is regulated by HIF1alpha-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer. PLoS One. 2012;7:e44108. doi:10.1371/journal.pone.0044108.CrossRefPubMedPubMedCentralGoogle Scholar
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  18. Malmberg EK, Pelaseyed T, Petersson AC, Seidler UE, De JH, Riordan JR, Hansson GC. The C-terminus of the transmembrane mucin MUC17 binds to the scaffold protein PDZK1 that stably localizes it to the enterocyte apical membrane in the small intestine. Biochem J. 2008;410:283–9. doi:10.1042/BJ20071068.CrossRefPubMedGoogle Scholar
  19. Moniaux N, Junker WM, Singh AP, Jones AM, Batra SK. Characterization of human mucin MUC17. Complete coding sequence and organization. J Biol Chem. 2006;281:23676–85. doi:10.1074/jbc.M600302200.CrossRefPubMedGoogle Scholar
  20. Moniaux N, Nollet S, Porchet N, Degand P, Laine A, Aubert JP. Complete sequence of the human mucin MUC4: a putative cell membrane-associated mucin. Biochem J. 1999;338(Pt 2):325–33.PubMedPubMedCentralCrossRefGoogle Scholar
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  24. Rahn JJ, Shen Q, Mah BK, Hugh JC. MUC1 initiates a calcium signal after ligation by intercellular adhesion molecule-1. J Biol Chem. 2004;279:29386–90. doi:10.1074/jbc.C400010200.CrossRefPubMedGoogle Scholar
  25. Ramasamy S, Duraisamy S, Barbashov S, Kawano T, Kharbanda S, Kufe D. The MUC1 and galectin-3 oncoproteins function in a microRNA-dependent regulatory loop. Mol Cell. 2007;27:992–1004. doi:10.1016/j.molcel.2007.07.031.CrossRefPubMedPubMedCentralGoogle Scholar
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  27. Senapati S, Gnanapragassam VS, Moniaux N, Momi N, Batra SK. Role of MUC4-NIDO domain in the MUC4-mediated metastasis of pancreatic cancer cells. Oncogene. 2012;31:3346–56. doi:10.1038/onc.2011.505.CrossRefPubMedGoogle Scholar
  28. Shen Q, Rahn JJ, Zhang J, Gunasekera N, Sun X, Shaw AR, Hendzel MJ, Hoffman P, Bernier A, Hugh JC. MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1. Mol Cancer Res. 2008;6:555–67. doi:10.1158/1541-7786.MCR-07-2033.CrossRefPubMedGoogle Scholar
  29. Singh AP, Chaturvedi P, Batra SK. Emerging roles of MUC4 in cancer: a novel target for diagnosis and therapy. Cancer Res. 2007;67:433–6. doi:10.1158/0008-5472.CAN-06-3114.CrossRefPubMedGoogle Scholar
  30. Tang J, Zhu Y, Xie K, Zhang X, Zhi X, Wang W, Li Z, Zhang Q, Wang L, Wang J, Xu Z. The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer. J Exp Clin Cancer Res. 2016;35:91. doi:10.1186/s13046-016-0369-0.CrossRefPubMedPubMedCentralGoogle Scholar
  31. Tanida S, Mori Y, Ishida A, Akita K, Nakada H. Galectin-3 binds to MUC1-N-terminal domain and triggers recruitment of beta-catenin in MUC1-expressing mouse 3T3 cells. Biochim Biophys Acta. 2014;1840:1790–7. doi:10.1016/j.bbagen.2014.02.008.CrossRefPubMedGoogle Scholar
  32. Wang L, Chen H, Liu F, Madigan MC, Power CA, Hao J, Patterson KI, Pourgholami MH, O’Brien PM, Perkins AC, Li Y. Monoclonal antibody targeting MUC1 and increasing sensitivity to docetaxel as a novel strategy in treating human epithelial ovarian cancer. Cancer Lett. 2011;300:122–33. doi:10.1016/j.canlet.2010.09.013.CrossRefPubMedGoogle Scholar
  33. Wang L, Zhi X, Zhu Y, Zhang Q, Wang W, Li Z, Tang J, Wang J, Wei S, Li B, Zhou J, Jiang J, Yang L, Xu H, Xu Z. MUC4-promoted neural invasion is mediated by the axon guidance factor Netrin-1 in PDAC. Oncotarget. 2015;6:33805–22. doi:10.18632/oncotarget.5668.CrossRefPubMedPubMedCentralGoogle Scholar
  34. Wei X, Xu H, Kufe D. MUC1 oncoprotein stabilizes and activates estrogen receptor alpha. Mol Cell. 2006;21:295–305. doi:10.1016/j.molcel.2005.11.030.CrossRefPubMedGoogle Scholar
  35. Zhang L, Vlad A, Milcarek C, Finn OJ. Human mucin MUC1 RNA undergoes different types of alternative splicing resulting in multiple isoforms. Cancer Immunol Immunother. 2013;62:423–35. doi:10.1007/s00262-012-1325-2.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Rahat Jahan
    • 1
  • Sukhwinder Kaur
    • 1
  • Muzafar A. Macha
    • 1
    • 2
  • Surinder K. Batra
    • 1
    • 3
    • 4
    Email author
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Department of Otolaryngology-Head and Neck SurgeryUniversity of Nebraska Medical CenterOmahaUSA
  3. 3.Buffett Cancer CenterUniversity of Nebraska Medical CenterOmahaUSA
  4. 4.Eppley Institute for Research in Cancer and Allied DiseasesUniversity of Nebraska Medical CenterOmahaUSA