Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Nonmuscle Myosin II

  • Alba Juanes-García
  • Clara Llorente-González
  • Miguel Vicente-ManzanaresEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101734


Heavy chain:  NMMHC-II;  MHCII; zipper (in Drosophila). Three isoforms are expressed in mammalian cells, also known as: (1) MHCII-A; myosin-9= MHA= FTNS= EPSTS= BDPLT6= DFNA17= NMMHCA= NMHC-II-A= NMMHC-IIA; (2) MHCII-B=myosin-10= NMMHCB= NMMHC-IIB; (3) MHCII-C=myosin-14= DFNA4= DFNA4A= FP17425= MHC16= MYH17= NMHC II-C= NMHC-II-C= PNMHH= myosin. Arabic numbers are now used too, e.g., myosin 2

Regulatory light chain:  RLC;  MLC;  MRLC;  MYRL; spaghetti squash (in Drosophila). Three isoforms are expressed in mammalian cells, also known as: (1) SM (smooth muscle)-RLC= MYL9= LC20= MLC-2C= MLC2= MRLC1= MYRL2; (2) MYL12A= HEL-S-24= MLC-2B= MLCB= MRCL3= MRLC3= MYL2B; (3) MYL12B= MLC-B=MRLC2

Essential light chain: MYL6= ELC= MLC= MLC-ALK= MLC1 (in Drosophila)

Functional unit (2×HC+2×RLC+2×ELC): NMII, NMMII, cytoplasmic myosin II

Historical Background

The discovery of nonmuscle myosin II (NMII) is linked to the story of muscle contraction (reviewed in Szent-Gyorgyi 2004). It started in...

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We regret the large number of original articles that were left out due to space constraints. Dr. Vicente-Manzanares would like to thank Prof. Robert S. Adelstein, Dr. Mary Anne Conti and Dr. Xuefei Ma for critical reading of the manuscript and their advice, help and warm friendship over the years. This work was funded by grant SAF2014-54705-R from MINECO. Miguel Vicente-Manzanares is a Ramon y Cajal Assistant Professor (RYC2010-06094).


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Alba Juanes-García
    • 1
  • Clara Llorente-González
    • 1
    • 2
  • Miguel Vicente-Manzanares
    • 1
    • 2
    Email author
  1. 1.Department of Medicine, Universidad Autonoma de Madrid School of MedicineU.D. Hospital Universitario de la PrincesaMadridSpain
  2. 2.Instituto de Biología Molecular y Celular del Cáncer-CSICSalamancaSpain