Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Munetaka HiroseEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101731


Historical Background

Nerve growth factor (NGF) was discovered by Rita Levi-Montalcini, who revealed that mouse sarcomas transplanted into chicken embryos secrete a factor into the blood that induces sensory and sympathetic nerve growth (Levi-Montalcini 1952; Levi-Montalcini 1987). She was awarded the Nobel Prize in 1986 for this work (Abott 2009). NGF is indispensable for the prenatal growth of sensory and sympathetic nerves. Two NGF receptors have been identified, one with high affinity and the other with low affinity for NGF (Landreth and Shooter 1980); these were later named tropomyosin receptor kinase (Trk) A and p75 neurotrophin receptor (p75NTR), respectively. NGF was also identified as a key molecule in the development of basal forebrain...

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Anesthesiology and Pain MedicineHyogo College of MedicineNishinomiyaJapan