Skip to main content
SpringerLink
Log in

NGF

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 119 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 4,499.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 4,499.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Abbott A. One hundred years of Rita. Nature. 2009;458:564–7.

    Article  CAS  PubMed  Google Scholar 

  • Aloe L, Rocco ML, Bianchi P, Manni L. Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med. 2012;10:239.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Artim SC, Mendrola JM, Lemmon MA. Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. Biochem J. 2012;448:213–20.

    Article  PubMed  CAS  Google Scholar 

  • Bandtlow CE, Heumann R, Schwab ME, Thoenen H. Cellular localization of nerve growth factor synthesis by in situ hybridization. EMBO J. 1987;6:891–9.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139:267–84.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL, Hondermarck H. NGF and proNGF: regulation of neuronal and neoplastic responses through receptor signaling. Adv Biol Regul. 2015;58:16–27.

    Article  CAS  PubMed  Google Scholar 

  • Bucci C, Alifano P, Cogli L. The role of Rab protein in neuronal cells and in the trafficking of neurotrophin receptors. Membranes. 2014;4:642–77.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cunningham ME, Greene LA. A function-structure model for NGF-activated TRK. EMBO J. 1998;17:7282–93.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Chen KS, Nishimura MC, Armanini MP, Crowley C, Spencer SD, Phillips HS. Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J Neurosci. 1997;17:7288–96.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Einarsdottir E, Carlsson A, Minde J, Toolanen G, Svensson O, Solders G, Holmgren G, Holmberg D, Holmberg M. A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. Human Mol Genet. 2004;8:799–80.

    Article  CAS  Google Scholar 

  • Hirose M, Kuroda Y, Murata E. NGF/TrkA signaling as atherapeutic target for pain. Pain Pract. 2016;16:175–82.

    Article  PubMed  Google Scholar 

  • Indo Y, Tsuruta M, Hayashida Y, Karim MA, Ohta K, Kawano T, Mitsubuchi H, Tonoki H, Awaya Y, Matsuda I. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet. 1996;13:485–8.

    Article  CAS  PubMed  Google Scholar 

  • Iulita MF, Cuello AC. Nerve growth factor metabolic dysfunction in Alzheimer’s disease and Down syndrome. Trends Pharmacol Sci. 2014;35:338–48.

    Article  CAS  PubMed  Google Scholar 

  • Khan N, Smith MT. Neurotrophins and neuropathic pain: role in pathobiology. Molecules. 2015;20:10657–88.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Krock E, Currie JB, Weber MH, Ouellet JA, Stone LS, Rosenzweig DH, Haglund L. Nerve growth factor is regulated by toll-like receptor 2 in human intervertebral disks. J Biol Chem. 2016;291:3541–51.

    Article  CAS  PubMed  Google Scholar 

  • Lambiase A, Mantelli F, Sacchetti M, Rossi S, Aloe L, Bonini S. Clinical applications of NGF in occular diseases. Arch Ital Biol. 2011;149:283–92.

    PubMed  Google Scholar 

  • Landreth GE, Shooter EM. Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states. Proc Natl Acad Sci USA. 1980;77:4751–5.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Levi-Montalcini R. Effects of mouse tumor transplantation on the nervous system. Ann NY Acad Sci. 1952;55:330–43.

    Article  CAS  PubMed  Google Scholar 

  • Levi-Montalcini R. The nerve growth factor 35 years later. Science. 1987;237:1154–62.

    Article  CAS  PubMed  Google Scholar 

  • Marlin MC, Li G. Biogenesis and function of the NGF/TrkA signaling endosome. Int Rev Cell Mol Biol. 2015;314:239–57.

    Article  PubMed  Google Scholar 

  • Miranda C, Di Virgilio M, Selleri S, Zanotti G, Pagliardini S, Pierotti MA, Greco A. Novel pathogenic mechanisms of congenital insensitivity to pain with anhidrosis genetic disorder unveiled by functional analysis of neurtrophic tyrosine receptor kinase type 1/nerve growth factor receptor mutations. J Biol Chem. 2002;277:6455–62.

    Article  CAS  PubMed  Google Scholar 

  • Mitchell DJ, Blasier KR, Jeffery ED, Ross MW, Pullikuth AK, Suo D, Park J, Smiley WR, Lo KW, Shabanowitz J, Deppmann CD, Trinidad JC, Hunt DF, Catling AD, Pfister KK. Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. J Neurosci. 2012;32:15495–510.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Otten U, Gadient RA. Neurotrophins and cytokimes – intermediaries between the immune and nervous systems. Int J Dev Neurosci. 1995;13:147–51.

    Article  CAS  PubMed  Google Scholar 

  • Wiesmann C, de Vos AM. Nerve growth factor: structure and function. Cell Mol Life Sci. 2001;58:748–59.

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto M, Sobue G, Yamamoto K, Terao S, Mitsuma T. Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, TrkA, TrkB, and TrkC) in the adult human peripheral nervous system and nonneural tissues. Neurochem Res. 1996;21:929–38.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology and Pain Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan

    Munetaka Hirose

Authors
  1. Munetaka Hirose
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Munetaka Hirose .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2018 Springer International Publishing AG

About this entry

Check for updates. Verify currency and authenticity via CrossMark

Cite this entry

Hirose, M. (2018). NGF. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101731

Download citation

Publish with us

Policies and ethics

Search

Navigation