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MAPK Interacting Protein Kinase 1 and 2 (Mnk1 and Mnk2)

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  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

MAPK interacting serine/threonine kinase 1; MAPK interacting serine/threonine kinase 2; MKNK1; MKNK2

Historical Background

The MAPK interacting protein kinases 1 and 2 were identified as a part of a screen to identify novel proteins that can be phosphorylated by extracellular regulated kinase (Erk) (Fukunaga and Hunter 1997). This screen identified Mnk1 as an Erk2 substrate. Additionally Mnk1 was found to be phosphorylated by the p38 MAPK and the Erk kinase but not by c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) (Fukunaga and Hunter 1997). Stimulation with 12-O-tetradecanoylphorbol-13-acetate, fetal calf serum, anisomycin, UV irradiation, tumor necrosis factor-alpha, interleukin-1beta, or osmotic shock also resulted in phosphorylation of Mnk1 in an Erk and/or p38-dependent manner (Fukunaga and Hunter 1997). Another study utilizing a two-hybrid screen approach to identify novel Erk2 substrates identified Mnk1 as an Erk2 target (Waskiewicz et al. 1997)....

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Authors and Affiliations

  1. Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA

    Sonali Joshi

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  1. Sonali Joshi
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Correspondence to Sonali Joshi .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Joshi, S. (2018). MAPK Interacting Protein Kinase 1 and 2 (Mnk1 and Mnk2). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101722

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