Historical Background
Ikeda and colleagues were the first to refer to MASPs, in 1987. They described MASP-1 as the activating component of the mouse bactericidal Ra-reactive factor (RaRF). RaRF circulates in plasma as a complex of mannose-binding lectin (MBL) and serine proteases, activating the complement factors C4 and C2 upon binding to lipopolysaccharides in Ra chemotype Salmonella (Gram-negative) bacteria (Ikeda et al. 1987). Five years later, Matsushita and Fujita identified MASP-1 in serum, complexed with MBL (Matsushita and Fujita 1992). Thiel et al. identified a second MASP in 1997, named MASP-2 (Thiel et al. 1997). In 2001, Dahl and colleagues designated another protease as MASP-3, due to its homology to the other MASPs. The MASP1gene encodes MASP-1, MASP-3, and a truncated protein of...
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Boldt, A.B.W., Boschmann, S.E., Catarino, S.J., Andrade, F.A., de Messias-Reason, I.J. (2018). MASP1 and MASP2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101714
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101714
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