Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Angelica Beate Winter Boldt
  • Stefanie Epp Boschmann
  • Sandra Jeremias Catarino
  • Fabiana Antunes Andrade
  • Iara José de Messias-ReasonEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101714


Historical Background

Ikeda and colleagues were the first to refer to MASPs, in 1987. They described MASP-1 as the activating component of the mouse bactericidal Ra-reactive factor (RaRF). RaRF circulates in plasma as a complex of mannose-binding lectin (MBL) and serine proteases, activating the complement factors C4 and C2 upon binding to lipopolysaccharides in Ra chemotype Salmonella (Gram-negative) bacteria (Ikeda et al. 1987). Five years later, Matsushita and Fujita identified MASP-1 in serum, complexed with MBL (Matsushita and Fujita 1992). Thiel et al. identified a second MASP in 1997, named MASP-2 (Thiel et al. 1997). In 2001, Dahl and colleagues designated another protease as MASP-3, due to its homology to the other MASPs. The MASP1gene encodes MASP-1, MASP-3, and a truncated...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Angelica Beate Winter Boldt
    • 1
  • Stefanie Epp Boschmann
    • 2
  • Sandra Jeremias Catarino
    • 2
  • Fabiana Antunes Andrade
    • 2
  • Iara José de Messias-Reason
    • 2
    Email author
  1. 1.Department of GeneticsUniversidade Federal do Paraná (UFPR)CuritibaBrazil
  2. 2.Department of Clinical Pathology, Hospital de ClínicasUniversidade Federal do Paraná (UFPR)CuritibaBrazil