Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Huai-Chia Chuang
  • Tse-Hua TanEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101713


Historical Background

The serine/threonine kinase GCK-like kinase (GLK) is first identified by screening a human skeletal muscle cDNA library using degenerate oligonucleotide PCR primers (Diener et al. 1997). The nucleotide sequence of GLK encodes an open reading frame of 894 amino acids with a calculated molecular mass of 100 kDa. GLK shares 57% amino acid identity with MAP4K2 (also named germinal center kinase; GCK) and 49% amino acid identity with MAP4K1 (also named hematopoietic progenitor kinase 1 (HPK1)) (Hu et al. 1996; Diener et al. 1997). Thus, GLK is classified as a member of the MAP kinase kinase kinase kinase (MAP4K) family and also named MAP4K3. The MAP4K3/GLK protein contains a conserved N-terminal kinase domain, three proline-rich regions, and a conserved C-terminal citron homology domain (Fig. 1). Three splice variants of...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Immunology Research Center, National Health Research InstitutesZhunanTaiwan