Synonyms
Historical Background
Matrix metalloproteinase-2 (MMP-2), previously named 72 kDa type IV collagenase or gelatinase A, belongs to the MMP family of calcium and zinc-dependent endopeptidases. MMPs were originally considered to be secreted proteases which play a major role in degrading extracellular matrix (ECM) proteins. In addition to its canonical role in ECM remodelling, MMP-2 has many nonmatrix extracellular and intracellular substrates (Schulz 2007; Spinale 2007). The list of identified MMP-2 substrates continues to grow and includes sarcomeric proteins, membrane receptors, cytokines, and growth factors. Consequently, MMP-2 regulates a vast range of physiological processes, from angiogenesis to wound healing and tissue remodeling. However, aberrant activation of MMP-2 contributes to many pathophysiological conditions, including inflammation, cancer metastasis, and cardiovascular diseases, making it a target of interest for therapeutic...
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Acknowledgments
We thank Dawne Colwell for her help with graphics. Research in the Schulz lab is supported by the Canadian Institutes of Health Research (FDN 143299) and the Heart and Stroke Foundation of Canada. Brandon Chan received a WCHRI graduate studentship award which is funded by the support of the Stollery Children’s Hospital Foundation through the Women and Children’s Health Research Institute.
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Chan, B.Y.H., Roczkowsky, A., Ilarraza, R., Schulz, R. (2018). Matrix Metalloproteinase-2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101708
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DOI: https://doi.org/10.1007/978-3-319-67199-4_101708
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