HGF (Hepatocyte Growth Factor)
In 1984, hepatocyte growth factor (HGF) was first reported as a potent mitogen of rat hepatocytes in a primary culture. The primary structure of HGF became evident with cDNA cloning in 1989, and HGF was simultaneously identified as a novel growth factor (Nakamura et al. 1989; Miyazawa et al. 1989). Meanwhile, scatter factor was identified from fibroblast-cultured media as a scattering-inducible factor toward epithelial cells. The biological activities of HGF and scatter factor seemed unrelated, but subsequent biochemical analysis has revealed that HGF and scatter factor are identical.
Initially, a transforming Met fusion protein, translocated promoter region (TPR)–Met, was discovered in a human osteosarcoma cell line as an active oncogene (Cooper et al. 1984). The proto-oncogene c-Met was later found to encode the transmembrane protein with intracellular tyrosine...
- Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale C-M, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Jänne PA. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 2007;316:1039–43.PubMedCrossRefGoogle Scholar
- Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, Gohda E, Daikuhara Y, Kitamura N. Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem Biophys Res Commun. 1989;163:967–73.PubMedCrossRefGoogle Scholar
- Schiering N, Knapp S, Marconi M, Flocco MM, Cui J, Perego R, Rusconi L, Cristiani C. Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a. Proc Natl Acad Sci U S A. 2003;100:12654–9.PubMedPubMedCentralCrossRefGoogle Scholar
- Wang W, Marimuthu A, Tsai J, Kumar A, Krupka HI, Zhang C, Powell B, Suzuki Y, Nguyen H, Tabrizizad M, Luu C, West BL. Structural characterization of autoinhibited c-Met kinase produced by coexpression in bacteria with phosphatase. Proc Natl Acad Sci U S A. 2006;103:3563–8.PubMedPubMedCentralCrossRefGoogle Scholar