Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MASP-1

  • Péter Gál
  • József Dobó
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_101691
How to cite

Synonyms

 Complement-activating component of Ra-reactive factor;  CRARF;  CRARF1;  Mannose (mannan)-binding lectin (MBL)-associated serine protease 1;  PRSS5;  Ra-reactive factor;  Ra-reactive factor serine protease P100;  Serine protease 5

Historical Background

In the late 1980s, a new activation pathway of the complement system, the lectin pathway, was discovered. The complement system is a proteolytic cascade system which forms an effector arm of innate immunity (Ricklin et al. 2010). The complement system is capable of labeling and eliminating invading pathogens (e.g., bacteria, fungi) and dangerously altered host cells (e.g., cancer cells, apoptotic cells). In this way, the complement system contributes to the protection against infection and to the maintenance of the homeostasis of the body. There are three ways through which the complement cascade can be activated. The classical and the alternative pathways of complement activation had been known for decades, when (in 1987)...

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References

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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Institute of Enzymology, Research Centre for Natural SciencesHungarian Academy of SciencesBudapestHungary