Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • André Patrick ArrigoEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101690


Historical Background

Heat shock proteins (Hsps) were first described by Tissières in 1974 in the salivary glands of Drosophila third instar larvae exposed to sub-lethal temperatures (temperature shift of 20–35 °C). Hsps were then discovered in all living organisms, from bacteria to human including plants (Lindquist and Craig 1988). Five families of heat shock proteins have been described: the HspH (large Hsps), 90 kDa (HspC-Hsp90), 70 kDa (HspA-Hsp70), 60 kDa (HspD-Hsp60), and the 20–30 kDa small heat shock proteins (HspB-small Hsps, sHsps). The interest in these proteins was stimulated by discovering that their expression can be triggered by many environmental stress conditions as well as by toxins known to alter the folding of proteins.This lead to the finding that Hsps are molecular chaperones whose function is to attenuate stress-induced damages in protein folding and...

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  1. Arrigo A-P. In search of the molecular mechanism by which small stress proteins counteract apoptosis during cellular differentiation. J Cell Biochem. 2005;94(2):241–6.PubMedCrossRefGoogle Scholar
  2. Arrigo A-P. Pathology-dependent effects linked to small heat shock proteins expression. Scientifica. 2012;2012:185641.  https://doi.org/10.6064/2012/185641.CrossRefPubMedPubMedCentralGoogle Scholar
  3. Arrigo A-P. Human small heat shock proteins: protein interactomes of homo- and hetero-oligomeric complexes: an update. FEBS Lett. 2013;587(13):1959–69.PubMedCrossRefGoogle Scholar
  4. Arrigo A-P, Gibert B. Protein interactomes of three stress inducible small heat shock proteins: HspB1, HspB5 and HspB8. Int J Hyperth. 2013;29(5):409–22.CrossRefGoogle Scholar
  5. Arrigo A-P, Gibert B. HspB1, HspB5 and HspB4 in human cancers: potent oncogenic role of some of their client proteins. Cancers (Basel). 2014;6(1):333–65.CrossRefGoogle Scholar
  6. Arrigo A-P, Welch W. Characterization and purification of the small 28,000-dalton mammalian heat shock protein. J Biol Chem. 1987;262:15359–69.PubMedGoogle Scholar
  7. Arrigo A-P et al. Hsp27 consolidates intracellular redox homeostasis by upholding glutathione in its reduced form and by decreasing iron intracellular levels. Antioxid Redox Signal. 2005;7(3–4):414–22.PubMedCrossRefGoogle Scholar
  8. Bruey JM, et al. Differential regulation of HSP27 oligomerization in tumor cells grown in vitro and in vivo. Oncogene. 2000;19(42):4855–63.PubMedCrossRefGoogle Scholar
  9. Ciocca DR, et al. Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update. Arch Toxicol. 2013;87(1):19–48.PubMedPubMedCentralCrossRefGoogle Scholar
  10. Garrido C, et al. Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer Res. 1998;58(23):5495–9.Google Scholar
  11. Gibert B, et al. Knock down of heat shock protein 27 (HspB1) induces degradation of several putative client proteins. PLoS One. 2012;7(1):e29719.PubMedPubMedCentralCrossRefGoogle Scholar
  12. Kappe G, et al. The human genome encodes 10 alpha-crystallin-related small heat shock proteins: HspB1-10. Cell Stress Chaperones. 2003;8(1):53–61.CrossRefGoogle Scholar
  13. Lindquist S, Craig EA. The heat-shock proteins. Annu Rev Genet. 1988;22:631–77.PubMedCrossRefGoogle Scholar
  14. Mehlen P, et al. Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death. J Biol Chem. 1996;271(28):16510–4.PubMedCrossRefGoogle Scholar
  15. Mehlen P, et al. Hsp27 as a switch between differentiation and apoptosis in murine embryonic stem cells. J Biol Chem. 1997;272:31657–65.PubMedCrossRefGoogle Scholar
  16. Mymrikov EV, et al. The pivotal role of the beta 7 strand in the intersubunit contacts of different human small heat shock proteins. Cell Stress Chaperones. 2010;15(4):365–77.Google Scholar
  17. Paul C, et al. Dynamic processes that reflect anti-apoptotic strategies set up by HspB1 (Hsp27). Exp Cell Res. 2010;316(9):1535–5.PubMedCrossRefGoogle Scholar
  18. Pichon S, et al. Control of actin dynamics by p38 MAP kinase – Hsp27 distribution in the lamellipodium of smooth muscle cells. J Cell Sci. 2004;117 Pt 12:2569–7.PubMedCrossRefGoogle Scholar
  19. Sromer T, et al. Analysis of the interaction of small heat shock proteins with unfolding proteins. J Biol Chem. 2003;278(20):18015–21.Google Scholar
  20. Taipale M, et al. HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol. 2010;11(7):515–28.PubMedCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Apoptosis, Cancer and Development Laboratory, UMR INSERM 1052-CNRS 5286, Lyon Cancer Research CenterClaude Bernard University Lyon1LyonFrance