Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Leukocyte Immunoglobulin-Like Receptor (LILR)

  • Kouyuki HirayasuEmail author
  • Hisashi Arase
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101689


Historical Background

The leukocyte immunoglobulin (Ig)-like receptor (LILR) multigene family consists of two pseudogenes (LILRP1 and LILRP2) and 11 functional genes that encode five activating (LILRA1, LILRA2, LILRA4, LILRA5, and LILRA6), five inhibitory (LILRB1, LILRB2, LILRB3, LILRB4, and LILRB5), and one soluble (LILRA3) form. The LILR gene family was independently discovered by different investigators around the same time. Immunoglobulin-like transcripts 1 and 2 (ILT1 and ILT2), which correspond to LILRA2 and LILRB1, respectively, were identified as novel molecules of the immunoglobulin superfamily (IgSF) using IgSF-related PCR primers (Samaridis and Colonna 1997). The leukocyte immunoglobulin-like receptor (LIR-1), which corresponds to LILRB1, was identified as the receptor for the human cytomegalovirus (HCMV) UL18 gene product, an HLA class I mimic (Cosman et al. 1997). MIR-7 and MIR-10, which correspond...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Laboratory of Immunochemistry, WPI Immunology Frontier Research CenterOsaka UniversityOsakaJapan
  2. 2.Department of Immunochemistry, Research Institute for Microbial Diseases, Osaka UniversityOsakaJapan