Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Hepatocyte Growth Factor Receptor

  • Simona Gallo
  • Paolo Maria Comoglio
  • Tiziana CrepaldiEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101684


 AUTS9;  c-MET;  DFNB97;  HGFR;  MET;  RCCP2

Historical Background

In the mid-1970s, Harold Varmus and Michael Bishop began the hunting for cancer genes in the cell genome. They provided evidence that the viral v-Src gene from avian sarcoma virus was taken up by the virus from host cells and incorporated in its genome. The v-Src was transforming since it encoded for a mutated tyrosine kinase protein. Like v-Src, oncogenes are mutant-activated versions of normal cellular genes, called “proto-oncogenes.” Harold Varmus and Michael Bishop’s theory of carcinogenesis explained how chemicals, X-rays, or other DNA injuries activated such endogenous proto-oncogenes, thus initiating cancer. The MET proto-oncogene was originally identified in 1984 in George Vande Woude’s lab, after a shiny decade of discoveries of cancer-causing genes. The treatment of a human osteogenic sarcoma cell line with a chemical carcinogen induced a chromosomal translocation of the TPR (translocated promoter...
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Simona Gallo
    • 1
    • 2
  • Paolo Maria Comoglio
    • 2
  • Tiziana Crepaldi
    • 1
    • 2
    Email author
  1. 1.Department of OncologyUniversity of TurinCandiolo, TurinItaly
  2. 2.Candiolo Cancer Institute - IRCCSCandiolo, TurinItaly