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MORG1 (Mitogen-Activated Protein Kinase Organizer 1)

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  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

WDR83; WD repeat domain 83

Historical Background

Mitogen-activated protein kinase organizer 1 (MORG1), also known as WDR83, is a member of the WD-40 domain protein family (Vomastek et al. 2004). The WD-40 domain exhibits a β-propeller architecture and is one of the most abundant domains and also among the top interacting domains in eukaryotic genomes (Xu and Min 2011). The WD-40 domain proteins function as an adaptor in many different protein complexes or protein-DNA complexes in very diverse cellular processes (Xu and Min 2011). Analysis of the mouse cDNA sequence showed that MORG1 is a protein of 315 amino acids composed almost entirely of seven WD-40 domains with a molecular mass of 34.5 kDa (Fig. 1) (Vomastek et al. 2004). Mammalian MORG1 shares >50% amino acid sequence identity with proteins of Drosophila melanogaster and Caenorhabditis elegans and is ubiquitously expressed, with abundant amounts in the heart, brain, liver, kidney, and testis (Vomastek et al. 2004). When...

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References

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Authors and Affiliations

  1. Department of Internal Medicine III, University Hospital Jena, 07747, Jena, Germany

    Ivonne Loeffler & Gunter Wolf

Authors
  1. Ivonne Loeffler
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  2. Gunter Wolf
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Corresponding author

Correspondence to Ivonne Loeffler .

Editor information

Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Loeffler, I., Wolf, G. (2018). MORG1 (Mitogen-Activated Protein Kinase Organizer 1). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101683

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