Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

MORG1 (Mitogen-Activated Protein Kinase Organizer 1)

  • Ivonne LoefflerEmail author
  • Gunter Wolf
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101683


Historical Background

Mitogen-activated protein kinase organizer 1 (MORG1), also known as WDR83, is a member of the WD-40 domain protein family (Vomastek et al. 2004). The WD-40 domain exhibits a β-propeller architecture and is one of the most abundant domains and also among the top interacting domains in eukaryotic genomes (Xu and Min 2011). The WD-40 domain proteins function as an adaptor in many different protein complexes or protein-DNA complexes in very diverse cellular processes (Xu and Min 2011). Analysis of the mouse cDNA sequence showed that MORG1 is a protein of 315 amino acids composed almost entirely of seven WD-40 domains with a molecular mass of 34.5 kDa (Fig. 1) (Vomastek et al. 2004). Mammalian MORG1 shares >50% amino acid sequence identity with proteins of Drosophila melanogaster and Caenorhabditis elegans and is ubiquitously expressed, with abundant amounts in the heart, brain, liver, kidney, and testis (Vomastek et al. 2004)....
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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Internal Medicine IIIUniversity Hospital JenaJenaGermany