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Kv5, Kv6, Kv8, and Kv9

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  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

Electrically silent voltage-gated K+(Kv) subunits: Kv5.1, IK8, kH1, KCNF1; Kv6.1, K13, kH2, KCNG1; Kv6.2, KCNG2; Kv6.3, Kv10.1, KCNG3; Kv6.4, Kv6.3, KCNG4; Kv8.1, Kv2.3, KCNV1; Kv8.2, Kv11.1, KCNV2; Kv9.1, KCNS1; Kv9.2, KCNS2; Kv9.3, KCNS3

Historical Background

The first members of the electrically silent voltage-gated K+ (Kv) subfamilies (Kv5, Kv6, Kv8, and Kv9, often referred to as KvS) were cloned in 1992. In contrast to the members of the previously cloned Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw), and Kv4 (Shal) subfamilies, the newly cloned Kv5.1 and Kv6.1 subunits did not produce voltage-dependent currents when expressed in heterologous expression systems (Drewe et al. 1992). Four years later, Kv8.1 was cloned and the effect of coexpressing Kv8.1 with Kv1–Kv4 subunits was examined, revealing that Kv8.1 affected Kv2 and Kv3 currents (Hugnot et al. 1996). This finding suggested that Kv8.1 interacts with other Kv subunits which was confirmed in the case of Kv8.1 and Kv2.1...

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References

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Authors and Affiliations

  1. University of Antwerp, Wilrijk, Antwerp, Belgium

    Elke Bocksteins

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  1. Elke Bocksteins
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Correspondence to Elke Bocksteins .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Bocksteins, E. (2018). Kv5, Kv6, Kv8, and Kv9. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101682

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