Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Lysophosphatidic Acid Receptor

  • Nobuyuki Fukushima
  • Tsuyoshi Kado
  • Toshifumi Tsujiuchi
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101681

Synonyms

Historical Background

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a fatty acid linked to sn-1 or sn-2 and a phosphate at 2n-3 position of the glycerol backbone (Fig. 1). Historically, LPA was considered to be a metabolite of membrane phospholipids until 1989, when it was suggested to act as an intercellular signaling molecule that stimulates cell proliferation through heterotrimeric G protein activation (van Corven et al. 1989). In 1996, the first LPA receptor gene ( Lpar1) was isolated as a G protein-coupled receptor (GPCR) gene predominantly expressed in the ventricular zone of the developing cerebral cortex of mice (Hecht et al. 1996). The mouse Lpar1 gene was originally termed ventricular zone gene-1 ( vzg-1), and the most related gene showing the highest percentage amino acid identity was endothelial...
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Notes

Acknowledgments

This work was supported by KINDAI research funding KD02 (N.F. and T.T.) and KINDAI School of Science and Engineering funding RK-052 and RK-062 (N.F.). We apologize to all authors whose primary research papers could not be cited directly due to space limitations.

References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Nobuyuki Fukushima
    • 1
  • Tsuyoshi Kado
    • 1
  • Toshifumi Tsujiuchi
    • 2
  1. 1.Division of Molecular Neurobiology, Department of Life ScienceKindai UniversityHigashiosakaJapan
  2. 2.Division of Molecular Oncology, Department of Life ScienceKindai UniversityHigashiosakaJapan