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Encyclopedia of Signaling Molecules pp 2869–2878Cite as

LILRB

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Synonyms

Leukocyte Immunoglobulin Like Receptor B1 (LILRB1): CD85J; LIR1; ILT2; MIR7; Leukocyte Immunoglobulin Like Receptor B2 (LILRB2): CD85D; LIR2; ILT4; MIR10; Leukocyte Immunoglobulin Like Receptor B3 (LILRB3): CD85A; LIR3; ILT5; HL9; Leukocyte Immunoglobulin Like Receptor B4 (LILRB4): CD85K; LIR5; ILT3; HM18; Leukocyte Immunoglobulin Like Receptor B5 (LILRB5): CD85C; LIR8

Historical Background

Immunoreceptor tyrosine-based inhibitory motif (ITIM) was first described in 1995. This conserved motif consists of six amino acids (S/I/V/LxYxxI/V/L) located in the cytoplasmic portion of certain transmembrane receptors (Daeron et al. 1995). Proteome-wide analysis identified 109 human ITIM-containing receptors (Staub et al. 2004). Conformational changes induced by ligand binding results in Src kinase-mediated phosphorylation of tyrosine in the ITIM, which in turn leads to the recruitment of SH2 domain-containing phosphatases. The ITIM-containing receptors bind tyrosine phosphatases SHP-1...

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Author information

Authors and Affiliations

  1. UT Southwestern Medical Center, Dallas, TX, USA

    Chengcheng Zhang

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  1. Chengcheng Zhang
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Correspondence to Chengcheng Zhang .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Zhang, C. (2018). LILRB. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101680

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