Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Leptin and Leptin Receptor

Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101679

Synonyms

Leptin [LEP; Leptin; Leptin (murine obesity homolog); Leptin (obesity homolog, mouse); OB; Obese protein; Obese, mouse, homolog of; Obesity factor; OBS].

Leptin receptor [CD295; DB; HuB219; LEP-R; LEPR; Leptin receptor; OB receptor; OB-R; OBR].

Historical Background

People long believed that obesity is entirely behavioral (e.g., lack of willpower) and not physiological. This dogma was first challenged with the identification of two obese mouse strains. The ob/ob mouse had been discovered in 1950 and characterized as the first model for massive obesity, marked hyperphagia, and mild transient diabetes. In 1965, a new obesity mutant had been discovered: the db/db mouse. Besides the marked obesity and hyperphagia, and unlike the ob/obmutant, these animals develop severe, life-shortening diabetes. The phenotypes suggested that the genes are involved in a common metabolic pathway. When a wild type mouse was parabioticaly paired (surgically joining of the bloodstream of two...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Medical Biotechnology Center, Faculty of Medicine and Health SciencesFlanders Institute for Biotechnology, Ghent UniversityGhentBelgium