Historical Background
Src-like adaptor protein 2 (SLAP2) was initially identified as an inhibitory protein of antigen receptor-mediated activation of lymphocytes (Holland et al. 2001). The SLAP family of proteins consists of two members, SLAP and SLAP2. Both SLAP and SLAP2 share similar structural features with SRC (Fig. 1). SLAP2 is expressed in a wide range of tissues including bone marrow, macrophages and hematopoietic cell lines (Kazi et al. 2015). Mice with targeted deletion of either SLAP2 or both SLAP and SLAP2 have been described with a weak phenotype (Dragone et al. 2009). However, SLAP2 has been shown to play important roles in antigen receptors and receptor tyrosine kinase signaling (Kazi et al. 2015).
SLAP, SLAP2, and SRC display similar structural features. SLAP family proteins, SLAP and SLAP2, share SRC homology 3 (SH3) and SRC homology 2 (SH2) domains with SRC. However, the kinase domain...
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Moharram, S.A., Rönnstrand, L., Kazi, J.U. (2018). Src-Like Adapter Protein 2 (SLAP2). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101669
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