Src-Like Adapter Protein (SLAP)
Reference work entry
Src-like adaptor protein (SLAP) is a 34 kDa protein which was initially identified in a yeast two-hybrid screen using the cytoplasmic domain of a receptor tyrosine kinase EPHA2 (Pandey et al. 1995). SLAP is an adapter protein which shares several structural features with SRC (Fig. 1). SLAP is expressed in a wide range of tissues and modulates signaling downstream of cell surface receptors. SLAP expression is not essential in embryonal development, as SLAP knockout mice did not display any critical physical abnormality and appeared to be healthy (Sosinowski et al. 2001). In adult mice, SLAP deficiency results in the higher T-cell receptor (TCR) signaling (Friend et al. 2013) and enhances the in vitro proliferation of osteoclast precursors (derived form of bone marrow macrophages) (Kim et al. 2010). Therefore, SLAP plays a role in controlling signaling downstream of receptors.
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