Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Src-Like Adapter Protein (SLAP)

  • Sausan A. Moharram
  • Lars Rönnstrand
  • Julhash U. Kazi
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_101668
How to cite

Synonyms

 SLA;  SLA1

Historical Background

Src-like adaptor protein (SLAP) is a 34 kDa protein which was initially identified in a yeast two-hybrid screen using the cytoplasmic domain of a receptor tyrosine kinase EPHA2 (Pandey et al. 1995). SLAP is an adapter protein which shares several structural features with SRC (Fig. 1). SLAP is expressed in a wide range of tissues and modulates signaling downstream of cell surface receptors. SLAP expression is not essential in embryonal development, as SLAP knockout mice did not display any critical physical abnormality and appeared to be healthy (Sosinowski et al. 2001). In adult mice, SLAP deficiency results in the higher T-cell receptor (TCR) signaling (Friend et al. 2013) and enhances the in vitro proliferation of osteoclast precursors (derived form of bone marrow macrophages) (Kim et al. 2010). Therefore, SLAP plays a role in controlling signaling downstream of receptors.
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References

  1. Dragone LL, Myers MD, White C, Gadwal S, Sosinowski T, Gu H, et al. Src-like adaptor protein (SLAP) regulates B cell receptor levels in a c-Cbl-dependent manner. Proc Natl Acad Sci U S A. 2006a;103:18202–7.  https://doi.org/10.1073/pnas.0608965103.CrossRefPubMedPubMedCentralGoogle Scholar
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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Sausan A. Moharram
    • 1
  • Lars Rönnstrand
    • 1
  • Julhash U. Kazi
    • 1
    • 2
  1. 1.Division of Translational Cancer Research, Department of Laboratory MedicineLund UniversityLundSweden
  2. 2.Laboratory of Computational Biochemistry, KN Biomedical Research InstituteBarisalBangladesh