Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi


  • Kaja Rupar
  • Julhash U. KaziEmail author
  • Lars Rönnstrand
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101666


 CD117;  C-Kit;  PBT;  SCFR

Historical Background

Protein tyrosine kinases (PTKs) are enzymes that catalyze the transfer of phosphate groups from ATP molecules to tyrosine residues of their substrates. PTKs can be divided into receptor tyrosine kinases (RTKs) and nonreceptor tyrosine kinases. In humans, there are 32 nonreceptor tyrosine kinases and 58 RTKs. RTKs can further be divided into 20 subfamilies depending on their domain arrangements (Lemmon and Schlessinger 2010). They are important components of cellular signaling pathways and regulate cell proliferation, survival, differentiation, metabolism, and motility. Because of their role in cellular signal transduction pathways, genetic changes that affect RTK activity can result in various diseases. RTKs are therefore attractive drug targets in many diseases including cancers. Among 20 RTK subfamilies, the type III receptor tyrosine kinase family, including platelet-derived growth factor receptors (PDGFA and PDGFB), colony...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Kaja Rupar
    • 1
  • Julhash U. Kazi
    • 1
    • 2
    Email author
  • Lars Rönnstrand
    • 1
  1. 1.Division of Translational Cancer ResearchDepartment of Laboratory Medicine, Lund UniversityLundSweden
  2. 2.Laboratory of Computational Biochemistry, KN Biomedical Research InstituteBarisalBangladesh