Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

GRB10

  • Nuzhat N. Kabir
  • Lars Rönnstrand
  • Julhash U. Kazi
Reference work entry
First Online:
DOI: https://doi.org/10.1007/978-3-319-67199-4_101665
How to cite

Synonyms

 Grb-10;  GRB-IR;  IRBP;  MEG1;  RSS

Historical Background

The Src Homology 2 (SH2) domain-containing adaptor proteins are a class of signal transducers downstream of growth factor receptors. The human genome encodes more than one hundred SH2 domain-containing proteins. The GRB7 family of SH2 domain-containing adaptor proteins includes three members: GRB7, GRB10, and GRB14. All three family members have the same domain structure (Fig. 1). Human GRB10 was originally identified in a yeast-two hybrid screen using the insulin receptor (IR) as bait and named as GRB-IR (Liu and Roth 1995).
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Nuzhat N. Kabir
    • 2
  • Lars Rönnstrand
    • 1
  • Julhash U. Kazi
    • 1
    • 2
  1. 1.Division of Translational Cancer Research, Department of Laboratory MedicineLund UniversityLundSweden
  2. 2.Laboratory of Computational BiochemistryKN Biomedical Research InstituteBarisalBangladesh