Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Early Growth Response 3 (EGR3)

  • Bianca Pfaffenseller
  • Bianca Wollenhaupt-Aguiar
  • Fábio Klamt
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101638

Synonyms

Historical Background

In 1991, the human EGR3 gene was first described by Patwardhan and colleagues. The EGR3 is an immediate early growth response gene first observed to be induced by mitogenic stimulation of rodent and human fibroblasts and monkey kidney epithelial cell line. The EGR3 cDNA sequence infers a 387 amino acid protein, and the EGR3 gene has a single intron and the cytogenetic location is 8p21.3 (Patwardhan et al. 1991).

The EGR3 is part of the early growth response (EGR) transcription factors family, which has five members: EGR1 (also known as ZIF268, NGFI-A, TIS8, KROX-24, or ZENK), EGR2 (also known as KROX-20), EGR3 (also known as PILOT), EGR4 (also known as NGFI-C or pAT133), and the product of the Wilms’ tumor gene, WT-1 (Pérez-Cadahía et al. 2011). The EGR family is characterized as immediate early genes (IEG) encoded transcription factors and has a highly conserved DNA-binding domain containing three zinc-finger motifs...
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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Bianca Pfaffenseller
    • 1
    • 2
  • Bianca Wollenhaupt-Aguiar
    • 1
    • 2
  • Fábio Klamt
    • 3
  1. 1.Laboratory of Cellular Biochemistry, Department of Biochemistry, Institute of Basic Health Science (ICBS)Federal University of Rio Grande do Sul (UFRGS)Porto AlegreBrazil
  2. 2.Laboratory of Molecular PsychiatryHospital de Clínicas de Porto Alegre (HCPA)Porto AlegreBrazil
  3. 3.Laboratory of Cellular Biochemistry, Department of BiochemistryInstitute of Basic Health Science (ICBS), Federal University of Rio Grande do Sul (UFRGS)St Porto AlegreBrazil