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Rab Geranylgeranyltransferase

  • Reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

GGTaseII; RabGGTase; Type II protein geranylgeranyltransferase

Historical Background

Many proteins interact with biological membranes in a transient way, and such interaction is a prerequisite of numerous cellular processes and vesicular transport, among others. Posttranslational lipid modification of a polypeptide results in a covalent attachment of the hydrophobic anchor and increased affinity of the particular peptide to cellular membranes. Two kinds of lipid moieties are most often added to intracellular proteins: fatty acids or prenyl groups (reviewed in Wang and Casey 2016; Hentschel et al. 2016). Protein geranylgeranylation is the posttranslational modification leading to an attachment of a 20-carbon geranylgeranyl isoprenoid chain to a specific cysteine residue in a protein by a thioether bond. Rab geranylgeranyltransferase (RGGT, EC 2.5.1.60) is an enzyme responsible for di-geranylgeranylation of Rab proteins. The activity of this enzyme was first described in 1992...

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Author information

Authors and Affiliations

  1. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland

    Malgorzata Gutkowska

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  1. Malgorzata Gutkowska
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Correspondence to Malgorzata Gutkowska .

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Editors and Affiliations

  1. Department of Molecular Science and Technology, Ajou University, Suwon, Korea

    Sangdun Choi

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Gutkowska, M. (2018). Rab Geranylgeranyltransferase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101635

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