Historical Background
Cofilin-1 is a major mediator of cytoskeleton dynamics as it regulates the remodeling of actin filaments (Carlier et al. 1999). It is ubiquitously expressed in all eukaryotes and has a broad tissue distribution. In mammals, for instance, it can be found in the brain, gastrointestinal tract, and lymphocytes. It was originally purified from avian and porcine brain as a 15–21 kDa globular protein with a core consisting of four or five beta-sheets surrounded by four or five alpha-helices. Its amino acid sequence and structure is highly conserved from yeast to human. In vivo and in vitro studies show that cofilin-1 protein can exist as both a monomer and oligomer, due mainly to the presence of four cysteine residues (Cys 39, Cys 80, Cys 139, and Cys 147) which are potential targets for oxidation (Fig. 1). This process can lead to disulfide bond formation, causing conformational changes in cofilin-1...
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Lopes, F.M., Coelho, J.C., Leal, M.H., Parsons, R.B., Klamt, F. (2018). CFL1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101634
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