Synonyms
Historical Background
For a long time, GABA (Fig. 1) was known only as a product of plant and microbial metabolism. It was first synthesized in 1883, and in 1950 it was realized that GABA is present in the mammalian central nervous system. As an inhibitory neurotransmitter, GABA was recognized in 1967 in experiments showing that nerve and muscle cells challenged by GABA undergo ion-mediated changes in conductance similar to those found following activation of inhibitory neurons (for review see Dreifuss et al. 1969). In the following years, dictinct roles, as well as biosynthetic and metabolic pathways of GABA were described, and its place of synthesis determined.
GABA molecule
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Josipa, V., Maja, J.J. (2018). GABA (γ-Aminobutyric Acid). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101632
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