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Filamin A

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Encyclopedia of Signaling Molecules

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References

  • Baldassarre M, Razinia Z, Brahme NN, Buccione R, Calderwood DA. Filamin A controls matrix metalloproteinase activity and regulates cell invasion in human fibrosarcoma cells. J Cell Sci. 2012;125(Pt 16):3858–69.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Baldassarre M, Razinia Z, Burande CF, Lamsoul I, Lutz PG, Calderwood DA. Filamins regulate cell spreading and initiation of cell migration. PLoS One. 2009;4(11):e7830.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Clark AR, Sawyer GM, Robertson SP, Sutherland-Smith AJ. Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders. Hum Mol Genet. 2009;18(24):4791–800.

    Article  PubMed  CAS  Google Scholar 

  • Clayton-Smith J, Walters S, Hobson E, Burkitt-Wright E, Smith R, Toutain A, et al. Xq28 duplication presenting with intestinal and bladder dysfunction and a distinctive facial appearance. Eur J Hum Genet. 2009;17(4):434–43.

    Article  PubMed  CAS  Google Scholar 

  • Ehrlicher AJ, Nakamura F, Hartwig JH, Weitz DA, Stossel TP. Mechanical strain in actin networks regulates FilGAP and integrin binding to filamin A. Nature. 2011;478(7368):260–3.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gorlin JB, Henske E, Warren ST, Kunst CB, D’Urso M, Palmieri G, et al. Actin-binding protein (ABP-280) filamin gene (FLN) maps telomeric to the color vision locus (R/GCP) and centromeric to G6PD in Xq28. Genomics. 1993;17(2):496–8.

    Article  PubMed  CAS  Google Scholar 

  • Hartwig JH, Stossel TP. Isolation and properties of actin, myosin, and a new actinbinding protein in rabbit alveolar macrophages. J Biol Chem. 1975;250(14):5696–705.

    PubMed  CAS  Google Scholar 

  • Kiema T, Lad Y, Jiang P, Oxley CL, Baldassarre M, Wegener KL, et al. The molecular basis of filamin binding to integrins and competition with talin. Mol Cell. 2006;21(3):337–47.

    Article  PubMed  CAS  Google Scholar 

  • Kyndt F, Gueffet JP, Probst V, Jaafar P, Legendre A, Le Bouffant F, et al. Mutations in the gene encoding filamin A as a cause for familial cardiac valvular dystrophy. Circulation. 2007;115(1):40–9.

    Article  PubMed  CAS  Google Scholar 

  • Lad Y, Kiema T, Jiang P, Pentikainen OT, Coles CH, Campbell ID, et al. Structure of three tandem filamin domains reveals auto-inhibition of ligand binding. EMBO J. 2007;26(17):3993–4004.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • McGrath MJ, Binge LC, Sriratana A, Wang H, Robinson PA, Pook D, et al. Regulation of the transcriptional coactivator FHL2 licenses activation of the androgen receptor in castrate-resistant prostate cancer. Cancer Res. 2013;73(16):5066–79.

    Article  PubMed  CAS  Google Scholar 

  • Nakamura F, Osborn TM, Hartemink CA, Hartwig JH, Stossel TP. Structural basis of filamin A functions. J Cell Biol. 2007;179(5):1011–25.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Nakamura F, Stossel TP, Hartwig JH. The filamins: organizers of cell structure and function. Cell Adhes Migr. 2011;5(2):160–9.

    Article  Google Scholar 

  • Razinia Z, Makela T, Ylanne J, Calderwood DA. Filamins in mechanosensing and signaling. Annu Rev Biophys. 2012;41:227–46.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Robertson SP. Filamin A: Phenotypic diversity. Curr Opin Genet Dev. 2005;15(3):301–7.

    Article  PubMed  CAS  Google Scholar 

  • Rognoni L, Most T, Zoldak G, Rief M. Force-dependent isomerization kinetics of a highly conserved proline switch modulates the mechanosensing region of filamin. Proc Natl Acad Sci USA. 2014;111(15):5568–73.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Ruskamo S, Gilbert R, Hofmann G, Jiang P, Campbell ID, Ylanne J, et al. The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended. Biochem J. 2012;446(2):261–9.

    Article  PubMed  CAS  Google Scholar 

  • Takafuta T, Wu G, Murphy GF, Shapiro SS. Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha. J Biol Chem. 1998;273(28):17531–8.

    Article  PubMed  CAS  Google Scholar 

  • Thompson TG, Chan YM, Hack AA, Brosius M, Rajala M, Lidov HG, et al. Filamin 2 (FLN2): a muscle-specific sarcoglycan interacting protein. J Cell Biol. 2000;148(1):115–26.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Wang K, Ash JF, Singer SJ. Filamin: A new high-molecular-weight protein found in smooth muscle and non-muscle cells. Proc Natl Acad Sci USA. 1975;72(11):4483–6.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, et al. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion. J Exp Med. 2010;207(11):2421–37.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

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Correspondence to David A. Calderwood .

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Baldassarre, M., Calderwood, D.A. (2018). Filamin A. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, Cham. https://doi.org/10.1007/978-3-319-67199-4_101630

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