Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

Tenascin-W (Tnn, TNN)

  • Martin Degen
  • Richard P. TuckerEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101623


Historical Background

Tenascins are glycoproteins found in the extracellular matrix of chordates (Chiquet-Ehrismann and Tucker 2011). Near their N-terminus tenascins have heptad repeats that support trimerization, and two trimers can be bound by disulfide bridges spanning N-terminal domains to form a hexabrachion. The N-terminal region is followed by one or more epidermal growth factor (EGF)-like domains that have a distinctive arrangement of cysteine residues (****C***C*****C****C*C********C). These are followed by a string of fibronectin type III (FNIII) domains and a C-terminal fibrinogen-related domain.

The original tenascin is tenascin-C (the “C” stands for cytotactin, a name given to this tenascin by one of its codiscoverers). Tenascin-C is the best studied of the tenascins and is prominently expressed in the embryo at sites of cell migration, epithelial-mesenchymal interactions, and in developing connective tissue. In the adult, tenascin-C is found at the...

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Orthodontics and Dentofacial OrthopedicsSchool of Dental Medicine, University of BernBernSwitzerland
  2. 2.Department of Cell Biology and Human AnatomyUniversity of CaliforniaDavisUSA