Tenascin-W (Tnn, TNN)
Tenascins are glycoproteins found in the extracellular matrix of chordates (Chiquet-Ehrismann and Tucker 2011). Near their N-terminus tenascins have heptad repeats that support trimerization, and two trimers can be bound by disulfide bridges spanning N-terminal domains to form a hexabrachion. The N-terminal region is followed by one or more epidermal growth factor (EGF)-like domains that have a distinctive arrangement of cysteine residues (****C***C*****C****C*C********C). These are followed by a string of fibronectin type III (FNIII) domains and a C-terminal fibrinogen-related domain.
The original tenascin is tenascin-C (the “C” stands for cytotactin, a name given to this tenascin by one of its codiscoverers). Tenascin-C is the best studied of the tenascins and is prominently expressed in the embryo at sites of cell migration, epithelial-mesenchymal interactions, and in developing connective tissue. In the adult, tenascin-C is found at the...
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