Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

GTP-Binding Protein Rheb

  • Jeffrey J. Heard
  • Fuyuhiko Tamanoi
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101614

Synonyms

 RHEB1;  RHEB2;  RHEBL1

Historical Background

Ras homolog enriched in brain (Rheb) plays a significant role in regulating protein synthesis, cell growth, cell cycle, and autophagy (Aspuria and Tamanoi 2004; Heard et al. 2014). Deregulation of Rheb signaling has been shown to cause diseases ranging from developmental disorders to cancer. Rheb was initially discovered as a protein sharing strong homology with Ras and whose expression was rapidly induced in brain neuronal cell by increased synaptic activity (Yamagata et al. 1994). Since then, Rheb has been shown to be widely expressed and to be conserved in eukaryotes from yeast to human. Higher eukaryotes express two Rheb proteins, Rheb1 and Rheb2 (RhebL1). Two separate genes encode these proteins that share 74% similarity. Their functions appear similar, but their tissue expression profiles differ significantly. Rheb is a member of the Ras superfamily of GTP-binding proteins that act as molecular switches in the cell to...

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References

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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Molecular Biology Institute, University of CaliforniaLos AngelesUSA
  2. 2.Department of Microbiology, Immunology and Molecular GeneticsUniversity of CaliforniaLos AngelesUSA