Encyclopedia of Signaling Molecules

2018 Edition
| Editors: Sangdun Choi

LGR4 (Leucine-Rich Repeat G-Protein Coupled Receptor 4)

  • Shiying Liu
  • Yue Yin
  • Weizhen ZhangEmail author
Reference work entry
DOI: https://doi.org/10.1007/978-3-319-67199-4_101612


Historical Background

Leucine-rich repeat G-protein-coupled receptors (LGRs) are a class of G-protein-coupled receptors characterized by a large extracellular domain containing several leucine-rich repeats (LRR) (Van Loy et al. 2008). According to phylogenetic analysis, there are three known LGR subgroups in mammals (Van Loy et al. 2008). Subtype A consists of receptors for glycoprotein including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and chorionic gonadotropin (CG). All of which are dimeric proteins composed of a common α-subunit and a hormone-specific β-subunit (Van Loy et al. 2008). In mammals, subtype C refers to LGRs 7–8. This type of LGR receptors contains a unique N-terminal low-density lipoprotein (LDL) motif (Van Loy et al. 2008). Subtype B is composed of three mammalian receptors LGR4–6 characterized by the presence of 13–18 leucine-rich repeats (LRRs) (Van Loy et al. 2008). Many...

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This work was supported by grants from the National Natural Science Foundation of China (81330010, 81390354) and American Diabetes Association grant #1-13-BS-225.


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© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.Department of Physiology and Pathophysiology, School of Basic Medical SciencesPeking University Health Science CenterBeijingChina
  2. 2.Department of SurgeryUniversity of Michigan Medical CenterAnn ArborUSA